Biomanufacturing, within the realm of synthetic biology (SynBio), involves using genetically engineered microorganisms to produce a wide array of chemical compounds and materials. These processes often leverage fermentation techniques to enable large-scale production.
It addresses the need for sustainable and environmentally friendly methods of producing chemicals and materials by reducing reliance on fossil fuels and minimizing waste compared to traditional manufacturing processes.
Engineered microbes are designed with specific genetic modifications to enhance their ability to produce desired chemicals or materials through metabolic pathways that can be tailored for the task at hand. The engineered cells are then cultured in bioreactors under controlled conditions, where they ferment using various substrates into the final product.
The process typically begins with selecting or engineering microorganisms, followed by their cultivation in bioreactors. The fermentation process is monitored for optimal conditions such as temperature, pH, and nutrient levels to maximize product yield.
This involves genetic engineering using CRISPR/Cas9 or other gene editing tools to introduce desired traits into the microbes. Next, these engineered cells are scaled up in bioreactors where they ferment with a suitable substrate to produce the target compound.
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