Gene-Edited Xenotransplantation

Gene-edited xenotransplantation involves transplanting organs from genetically modified pigs into humans to address the severe shortage of donor organs.

Addressing the chronic shortage of donor organs by using genetically modified pig organs as a viable alternative.

Donor pigs undergo extensive gene editing to remove pig-specific antigens and retroviruses, and to add human compatibility genes. The edited organs are then transplanted into recipients who are closely monitored for immune reactions and other complications.

• CRISPR
• pig organs
• antigens

The process involves complex genetic engineering techniques to modify pigs, followed by organ harvesting and preservation before transplantation.

Pigs are bred in controlled environments where their genes are edited using CRISPR or other gene-editing technologies. The organs are then harvested under sterile conditions and stored for transplantation.

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xenotransplantation

The transfer of living cells, tissues, or organs from one species to another.

gene editing

Techniques used to make specific changes in an organism’s DNA sequence.

immune rejection

A reaction by the recipient's immune system against transplanted tissue or organ.

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