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PART 1Executive Overview
1Definition

Antimicrobial resistance surveillance involves monitoring and analyzing genetic data from pathogens to track the emergence, spread, and evolution of drug-resistant bacteria. This is achieved through whole-genome sequencing (WGS) of pathogen isolates and linking these data to shared international databases for real-time tracking.

Category
Global Health
Best use
Tracking the rise of untreatable infection
Stage
NOW
2Problem It Solves

Surveillance addresses the challenge of drug-resistant infections by providing timely information on the emergence and spread of resistant pathogens, enabling public health officials to respond more effectively to outbreaks and implement targeted interventions.

3Lifecycle / Journey Stage
early commercial
PART 2Technical & Manufacturing
4How It Works

Pathogens are collected from clinical samples and undergo WGS. The genetic sequences are then uploaded to global databases, where they are compared with other sequenced isolates. This allows researchers to identify patterns, track the spread of resistance genes, and monitor the effectiveness of antimicrobial treatments in real time.

5Materials Used
6Manufacturing / Creation Process

The manufacturing process involves setting up laboratories equipped with next-generation sequencing (NGS) technology, bioinformatics software for data analysis, and secure data storage solutions. These facilities must maintain strict quality control measures to ensure the accuracy of genetic data.

7Build Process

Building an antimicrobial resistance surveillance system requires a multidisciplinary approach involving microbiologists, bioinformaticians, epidemiologists, and public health experts. The process includes sample collection, DNA extraction, sequencing, data analysis, and database management.

8Energy Requirements

Field units draw low hundreds of watts; fabrication is energy-intensive due to vacuum baking. Operational power requirements are moderate but can vary depending on the scale of sequencing operations.

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PART 3Market & Industry
9Companies Involved
WHO GLASSWellcome Sanger Institute

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10Estimated Costs

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11Case Studies

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PART 4Academic References
12Scientific Papers / White Papers

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13Patents

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14Glossary
Antimicrobial resistance (AMR)
The ability of microorganisms to survive and multiply in the presence of a substance that would normally kill them or inhibit their growth.
Whole-genome sequencing (WGS)
A method for determining the complete DNA sequence of an organism's genome. It is used to identify genetic variations, including those associated with drug resistance.
Bioinformatics
The application of computer science and information technology to the field of biology, particularly in the analysis and management of biological data such as DNA sequences.
15References

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Related Technologies

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